all are clearly better picks at SP.
Then you can debate guys like Zambrano, Peavy, Oliver Perez, Oswalt, Pedro, Hudson vs Prior.
It all depends on how big an injury risk you think Prior is and how much you are worried about what you saw last season. He is obviously going to go top 4 rounds and probably top 3. Is he worth it...a solid maybe. If you are someone like me who hates risk early and hates pitchers even more, then Prior is not someone you want to target in a fantasy draft come the third round. Those that took Prior last year in round 1 got roasted as he was one of the biggest fantasy flops of 2004. Caveat emptor.