Welcome aboard, krunchyfrogg! ("If we took the bones out, it wouldn't be crunchy, would it?"
+/- 50 isn't really a big deal at this point, and this year, more might be a good thing. In the case of a work stoppage, you want to have used as much of your ip allotment as possible in order to squeeze the most out of your team.
What's your league's scoring? I'd go by your needs here, using whatever pitchers give you the stats you need, with a tendency to burn more innings than you normally would (except in h2h, which is an awfully tough call this year).