Overall, I like your IF to help cover the OF. I'm not in a rush to trade any of your 3B's, since they all have spots that let them work.
I'm nervous about Reynolds. Yes, he hits a ton of HR's, but that average is a major category killer - and that power could be gone in a second (See Dunn, Adam for more on that). If you want to keep him for the HR's, then I'd try to get another high-AVG stick to help balance it out.
Kipnis might be another year away from really helping, so keep watch on the WW for some 2B help.
Unless you plan on moving HanRam to 3B (Which I wouldn't - his max value is still at SS, IMO), then I think you'd be better off dropping S. Drew and taking a flier on a 2B, in case Kipnis isn't quite ready yet. Reynolds? Murphy? Hill? Any of them available?
The good news about having a ton of speed is that there will always be another team who needs it badly, and will overpay for it. You'll have to wait and see how the season starts to play out, but I'd try to package one of your OF's for some power as soon as you can get someone good.
Rotation could be amazing if your Strassburg, Wainwright, and Johnson are all healthy. Figure only 1-2 of them will be, though. Nolasco makes me nervous. And angry, as I've rolled the dice on him a couple times before. So perhaps I'm just a jilted ex, but I'd be ready to drop or deal him in a heartbeat.
No issues with RP's - just be mindful of the usual closer roulette.
As of 8/4/13
C:Napoli 1B:Goldshmidt 2B:Kinsler, Gyorko SS:Tulo, Profar 3B:Longoria, Machado, Middlebrooks OF:Harper, J. Upton, AGon, R. Davis, Venable SP:Scherzer, Minor, Ryu, E.Santana, Beachy, Samardzja, J.Johnson (DL), T.Ross RP:Perez, Rodney, Farquar