Horcruxes are extremely difficult to destroy. They cannot be destroyed by conventional means such as smashing, breaking, or burning. To be destroyed, a Horcrux must suffer damage so severe that repair through magical means would be impossible.
In the Potter spirit, this is how I felt about Brandon Inge, but Detroit was finally able to rid themselves after putting up with months of arguably the worst offensive production in the majors (yes, even worse than Drew Butera). Who's your team's horcrux? What kind of move would you want to see your team make to destroy them?