Well there's no clear-cut answer. It depends on your league.
I am in a 20-team league and what I do is look at the three previous years' final category standings. I average what it would take (in the cumulative categories) to finish in about 17th place in each and use that as my goal. If you don't have access to that many stats, then just use last year's.
In my 20-team league it ends up being about 260 HR, between 1050 and 1150 RBI and R, 130 SB, 105 W, over 1000 K's, and I forget saves. It's either 75 or 90
Big diff there...