My preference seems unique to most here.
I prefer to either have the 2-3 or 10-11 picks of the draft.
This gives me the unique advantage of being able to better project the next 3-5 picks that will be made and apply them and adjust the best available theory. Reading a GMs mind is great advantage; by looking at who they already have and what our shared needs are makes it easier for me to decide when it is wise to reach for a player over taking best available.
Example: lets say I have the 10th pick, Picks 3(10) 4(3). I'm looking to address 1B & 3B here, the 11th/12th (next 4 picks) already have 1B but also need 3B. Votto is the best 1B available, Zimm the best 3B. VEventhough Votto maybe the best available player, I can more safely risk taking the lesser player (Zimmerman) because odds are good the two GMs will overlook Votto and he will still be available when my pick comes back around.
If my pick is 5-8 I would be more compelled to take the best available (Votto) rather then risk taking the lesser player and hope Zimmerman will still be available 9-12 picks later.
If you found my advice helpful, please help me