Some things I'm trying this year in H2H.........
-- Have a hitting heavy bench. My league has a 6 man bench, so I have 4 hitters and 2 pitchers. Means if multiple hitters have an unfavourable match up, they're subbed out and you accumulate something
-- Grab multi-position players for said bench. Zobrist/Coglan/Duncan etc.
-- Have one pitching roster spot that is a rotating door of spot starters (nearly) every day. If you are good enough at this it will help you far, far more then it will hurt you.
-- Don't be afraid to cut people if they aren't performing up to expectations, especially if you don't think they'll make the "being kept cut" at the end of the season.
-- Make a watch list of the elite players still in the high minors and know/keep an eye on who they're being blocked by.
The cafe usually has lots of little hidden gems of information if you look. For rookies there is a weekly article called Future Rookies, here is a link to the last one http://www.fantasybaseballcafe.com/2009/tips_futurerookies051909.php
BaseballHQ.com is worth a read, 3 months is $39 if you want more then the free stuff.