A reliever-intensive strategy works fine in H2H, but the thing to keep in mind is that relievers with potentially good ratios can be recovered in free agency. Guys like Hong-Chih Kuo, Taylor Buchholz, and Brad Ziegler were likely to go undrafted last season, but wound up being very useful. No need to touch upon the turnover in closers over the course of the season.
Personally, I'm the opposite: develop a very good starting rotation and spend reasonably on RP's. The more appearances you get from your quality starters, the likely your ERA and WHIP will be competitive enough barring any glaring fluctuations while keeping you in line for a volatile category such as wins.