Need a bit more data... H2H? Roto? 9x9 correct? Min/Max Innings Pitched (per week/season)?
Assuming that everybody is going to pitch near the same amount of innings pitched, counting categories like W, L, K, HR, GIDP should all be relatively equal.
Guys with top-tier closers are obviously going to excel in not only SV, but also have an advantage in ERA/WHIP over all those except the owners who have 3-5 ace starters.
But, if you're one of those owners who just has mediocre closers, who aren't going to give you an advantage in ERA/WHIP, then I don't really see any harm in dumping saves. With 9 pitching categories you've got plenty of room to make up for it, as long as you can fill your MR spots with guys who will give you an advantage in several categories (not just Holds).
If you can get high-market value for your middle-tier closers, I don't have a problem with this. If all you're going to do is trade mediocre closers for mediocre setup-men, you're not really helping yourself.