My strategy is to draft pure hitters, Best availible, for the first 4-5 rounds. I'll grab Santana if he drops in the last two picks of the 1st or into the 2nd. Then in 5-6 I'll grab the last of the peavy/zambrano/smoltz/etc. staff anchors. I'll continue to draft hitters until about the 10th, where I will take lots of high upside pitchers such as Hamels, Bush, Olsen, Schmidt, Burnett, etc. depending on availabilty, as well as one or two closers.
Near the end of the draft I will pick up some combination (2) of Broxton, Shields, Zumaya, Howry, and Duscherer. Not only will these guys step into closers roles should the top one get injured or suck, but two combine is the exact same as an ace starter.
I go for balanced speed (Guillen, Grady, C. Lee, etc.) over speed whores like Pierre, Roberts, and Crawford.
In H2H, your focus should be on power. You need some speed too, but not as much as you would need in a roto.
Focus your bench spots almost entirely on pitchers. I'll grab usually one or two bench hitter sleepers with high upside.
Hope I've helped.
Dodgers World Champs 2012