I have Mulder and the only situation where it might NOT be a no-brainer to pitch him would be if he was pitching against Pedro and I'm near my inning limit and desparate for a win.
Bluto: Over? Did you say over? NOTHING is over until WE decide it is! Was it over when the Germans bombed Pearl Harbor? HELL, NO!
Boon: Forget it, he's rolling.