I'm doing that in my H2H league this year. I drafted two starters (Peavy and Randy Johnson), and filled the rest of my slots with relievers. K-Rod, Turnbow, Duchscherer, Mike Gonzalez, Gagne, and Scot Shields. The thing is my league has an odd setup: only 15 innings requirement each week, and the categories are W, L, CG, SHO, SV, HR, K, TB, ERA, WHIP. I was very fortunate to pick up Papelbon as well.
Basically my strategy was, if i throw peavy and/or johnson out there for whatever start looks most appealing that week, my other relievers can eat up the rest of the innings, and over the course of the season I should normally win categories like SV, HR, TB, ERA, and Whip without much struggle. Wins and losses are also possible to win, as are CG & SHO since they're so random.
Anyways I ended up trading Turnbow for Beltran (yeah... i know) and my strategy is working pretty well thus far. In my opinion, scot shields is a very valuable player, especially if your league has holds.