I guess you are talking about roto style. If you are going to pick a pitching category to punt, saves is the obvious one. Some people will load up with starters to try to gain an edge in wins and ks. I have done that in the past, built up a lead in each through to August, then switch out the less productive starters for the hot middle and set up relief of that year. It lets me keep the lead in both those categories and work on lowering my WHIP and ERA. I do always start at least two closers though.
But that strategy changes as well, depending on what other owners are doing. In the past, I have also taken dominant closers, started 4 of them, along with a set up guy and just used four starters for the year, finishing in the lower tiers of k's and wins. Luckily in that year, my hitting was dominant so I was able to win. I finished first in ERA, WHIP, and saves in the pitching cats.
You can win with any strategy, and just like going to war, strategy has to change on the fly, depending on what your opponents are doing. That's one of the things I like about the game, you have to constantly change your pattern if it is working, as the other owners will just copy it.