Tough to say as you never want to take a closer that high at the start of the season as their probuction is very unpredictable. But mid-season could be different. I've never done one.
I think the approach of best player available is a good one for rounds 1 and 2. After that, filling shallow positions (like SS, 2B, C and maybe even RP in mid-season draft) could help you if you take a position scarcity type apporach.
It's always easier to get a contributing SP, OF, 1B, 3B later in the draft as a lot of teams will draft best player available. But the difference between Aramis Ramirez in the 2nd/3rd v. David Wright in the 5th/6th isn't too far off. That way you can get a much stronger player at SS and 2B.
You won't have as much production from your 3B spot, but you'll have more from your team overall with that approach.
That's my approach, but not the only way to go.
Hope that helps. Good luck in the draft.
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