Just some quick observations. In terms of your offense, patience may be your best weapon. A-Rod and Chipper have had a terrible start, and Bagwell has hit .300 and nothing else. At the end of the season, all 3 will be top 20 fantasy players. No reason to push the panic button on these.
I notice you have two superstar third basemen. Have you thought about trying to trade one away to try to fill a pitching need?
Your pitching: You have some worries, but you also have lots of potential. Jon Lieber has had somewhat of a slow start . Hopefully he will be a superstar again this year, if the Cubs offense comes around. Astacio is a make or break guy. He's making it big time right now. Keep him for now and start him, with a close eye when he starts against big offensive teams, which he hasn't yet. If you're looking for a free agent pitcher, I recommend picking up D'Amico on the Mets if you can, he's been available in most of my leagues. Looks like the Mets staff is legit. Vasquez is a concern for me too. I can't really comment on him though, because he's one of those guys that I see and say, "Oh, he's a top 10 pitcher? Really?" So the experts say. He's had a slow start. Wolf's been injured, should be above average to great, Appier is a finger-crosser, Duckworth's been awesome, and Sheets noteworthy.
In summation, your pitchin staff is volitile. It would have been great if you could anchor these guys with a solid veteran superstar like Schilling or Maddux, but c'est la vie. Lieber is close, but not quite. Concentrate on scouring ever bit of information about pitching you can, on your players and players that are available. Less attention is needed for your offense, but try to fill some of those holes around you superstars. Don't be afraid to get rid of hyped young upstarts that aren't panning out.
One more note: I don't like fantasy players like Marlon Anderson. Sure, he's going to get a crapload of hits and nice average, but look at his pitiful RBI, HR, and SB's. BORING! Take a chance on a hot 2B and have some fun.