Both are very strong top to bottom for the most part.
I would look to pick up another OF since I'm not a believer in Drew. Patterson could be a nice surprise, but I want to know where he's hitting in the lineup before I make my final decision on him.....The RP's are very solid, but I think you could use another solid SP myself. Sheets will anchor the rotation, and Harden will be a solid No. 2, but there are big question marks after that.
Same thing about Drew, but you've got a better OF to pick up for any slack he will create. Since you're obviously punting saves, I'd try to pick up a few SP's who will get you W's to balance that out. Halladay and Oswalt are great for your ratios, but I don't see either of them getting more than 14 W's, which would be OK, but you need W's since you won't get saves obviously. (If you understood that last sentence, could you explain it to me please.
Overall, of the two I'd take B since it's H2H. The offense is more balanced, and the SP's are probably the best on any one team in the league I'd venture to say.