They turn out really crazy and are all but impossible to draft for.
I played in a 10x10 last year and it was insane.
The draft found me spending all my time between picks trying to figure out which categories I needed help in and looking at stats to try to figure out who made sense.
As chris8 said, it is also pretty convoluted.
Was really tough.
Fun to do once, but don't know if I'm up to doing it again.
I've played leagues like this before. I hate them, but I can help you. They're not as hard to draft for as you might think.
The key to a league like this is to realize that you can't win every category. You are going to have weaknesses. There is no point to caring about all 24 categories. You want to build a team that can dominate in at least half the categories, so that your weaknesses can't kill you.
You have 13 hitting categories. There are no negative categories (categories where having less helps you). Many of the categories are repetitive. Speed is not that important - SB is just one of 13 categories, and while speed often affects triples, those will be a bit of a crapshoot from week to week. Don't worry about speed - spend your high picks on premium hitters with high OPS and most of the other categories will take care of themselves.
You have 11 pitching categories. 5 are positive (and 2 of those are CG and SHO which will often be 0-0 ties), 3 are ratios, and 3 are negative. There is no need to draft a lot of innings. Saves is just 1 of the 11 categories, so closers are not very valuable. If you get 1 or 2 really good starters early who keep the ERA and WHIP down, then fill in with great setup men late, you're set. You'll dominate the ratio categories, and also win L, R, and ER by virtue of throwing few innings. You'll lose saves, wins, and Ks, and sometimes CG and SHO... but to go 6-3 in pitching most weeks without spending high picks is great.
So to sum up the ideal draft strategy:
Draft a Santana, Unit, or Sheets in the first 2-3 rounds. Maybe 2 of them. Then fill out the rest of your hitting lineup, focusing on high OPS guys. No more pitchers until round 14. Then start picking up relief pitchers with great ERA, WHIP, and K/9. Try to find one or two that are SP eligible so you can pitch them in the SP spot.
If you follow that strategy and pick the right players, you'll dominate.