The thing about a 16-team league is that every team is going to have its problem spots. Even if you think you have the perfect team, injuries will occur and the waiver wire will look pretty bleak. Good quality reserve players are a must if you want to win these big leagues.
"And so he spoke, and so he spoke, that lord of Castamere. But now the rains weep o'er his hall, with no one there to hear." - The Rains of Castamere