You don't benefit much being a groundball pitcher on the Metrodome's turf. Being a groundball pitcher has more effects for someone like Zambrano with the slow grass of Wrigley. Santana's given up a bunch of HR's as well.
Santana threw far too many fastballs to the Sox over the weekend. The hits were rockets of the Sox bats (whether on the ground threw the INF or shots over the fence). I
I'd stick with Santana. He'd look much more impressive pitching the lefty-hitting heavy AL West. The Twins can't hit lefties if their life depended on it, but unfortunately he pitches for them.