C LaRue, Jason
1B Konerko, Paul
2B Soriano, Alfonso
3B Koskie, Corey
SS Womack, Tony
OF Walker, Larry
OF Drew, J.D.
OF Matsui, Hideki
Util Damon, Johnny
Bench Lee, Carlos
Bench Nixon, Trot
SP Moyer, Jamie
SP Wells, David
RP Gagne, Eric
RP Guardado, Eddie
P Urbina, Ugueth
P Foulke, Keith
P Simontacchi, Jason
Bench Jennings, Jason
Bench Stanton, Mike
Bench Dempster,
DL Milton, Eric
Your Strong areas: OF, Closers
Your Weak Areas: Starting Pitching, 3B/SS
You have a good outfield with Walker, Matsui, and Damon. Drew is hurt, but you can stash him on the DL. Nixon and Lee are good backups. You have 4 closers. That is two too many. I would try to trade them away, holding onto Gagne and Foulke. Trading Eddie Guardado might be smart because he is at a high point in value right now. Moyer and Wells are old, and will definately fall off from what they did last year. Koskie and Womack are decent, but could be improved if you traded away some backup OFs.
I'm not sure I like your starting pitching with Wells and Moyer, both are particularly old and offer questionable durability. I'd try and trade a closer (Guardado), for a younger arm. Drew is always a question mark and possibly will never produce as was predicted when he entered the league. If he stays healthy though, he could be a great pick.
"Never explain... you're friends already believe you and your enemies never will!" - Unknown
I would try to trade some RP for either SP or outfiled help. Maybe you can package a RP and one of your weaker OF's for an upgrade there. Other than that I think your team is pretty good.
I have to disagree with the other people who responded on one point. Trade away Gagne you will get much more relative value for Gagne than you will for Guardado. Just make offers sending Gagne to teams for a very elite hitter or pitcher. Hopefully someone will bite.