14 team, 5x5 roto, C/1B/2B/3B/SS/OF/OF/OF/U. 1250 Max IP.
We get 5 keepers. Two years ago I bought into the hype and drafted Wieters fairly early. When it came time to make a decision on keepers last year, I had Reyes/Pedroia/Holliday/Jason Bay as locks, with my 5th keeper coming down to Wieters and Hanson. Hanson was the safer pick, but I really believed that Wieters would take the next step and become a top 3 catcher at least, so I kept Wieters to my dismay.
It depends on how many keepers you get and the strength of your team, but taking a chance can set your team up for a while (especially in perennial keeper leagues).