Man, thats a tough one... my first thought is that you are selling low on all three of the guys you are dealing... but you are buying low on Lester, IMO
I'm not a big Cuddyer fan, I think there are guys on the FA market that are just as valuable as he is, especially in a 12-team league.
If you believe the Wieter hype, then I can see why you'd do the deal... but rookies are unpredictable, even ones as hyped as Wieters. Jeff Clement was supposed to rake last yr, but he didnt.
I'd lean towards "no" in the end. I think you are selling low on all three of the guys you are dealing and gambling too much on what you are getting back.