Not to sure about the AL 4x4 part, but if I had to choose I would go with Quentin/ Granderson. I also agree with ayebatter and I would take Cabrera over Rodriguez.
Quentin Vladdy - you lose the steals that Granderson gives you, but you get more reliable production in avg/hr/rbi (plus, Granderson only had 12 SBs in 553 ABs). You could go with Ortiz here (he has a better support lineup), but I think Vladdy is a little safer than Ortiz, but that is debatable.
Granderson will be gone by the time you draft your 4/5...but you can target McClouth in round 4/5 (you may even get him in 6/7). Some people might think that is a stretch, but the guy significantly outperformed Granderson last year. I know Granderson started the season on the DL, but McLouth only had 40 more ABs and still had a much better season:
If Granderson has 40 more ABs to even things out (10 games), his numbers look better (.280/119/25/71/15), but still trails RBI and SB by a good margin. He wins in runs, but your league doesn't count runs.
I think McClouth is pretty safe for 20/20, and if they end up hitting him 3rd, he should be pushing 100 RBI. In other words, you aren't giving up any HR/SB potential, but you get much better RBI potential...and drafted 2-4 rounds lower than Granderson. Sounds like a winner to me.
I would pass on Mauer. I realize he is one of the best at a thin position, but I think you do better by drafting for stats, not position, for at least the first five rounds (maybe even 8). After that, you can start looking at positions.