Fallout 3 looks really good but I'm probably gonna get SOCOM 3 when it's released in a couple weeks so if I'm too busy with SOCOM I might not get Fallout until later. I haven't kept up with upcoming releases so I'm not sure what the big titles are going to be on the PS3.
Also the expansion for World of Warcraft is coming out in November on PC so that will probably keep me busy for awhile too.
"My cat's breath smells like cat food." - R. Wiggum
Fable 2 for sure. Guitar Hero World Tour once I'm sick of Rock Band 2 songs. Mirrors Edge looks interesting and I'm also interested in seeing Tomb Raider as a full next gen release not a launch title port. Monopoly too, that could be fun online.
Most of all, I'm looking forward to the new Xbox dashboard especially Netflix (I'm sick of hooking my laptop to my tv) and the interactive games.