This game is pretty sweet- I like Oblivion more, but I can see myself really getting into this one. I'm really glad that they have the fast travel system like Oblivion.
POSSIBLE VERY EARLY IN THE GAME SPOILERS:
I don't play FPS very often though and I'm getting killed a ton. Should it take 6 shots to the head to kill a vicious dog? Should I be staying in Megaton right now and wait to do the side quests? I'm not sure what I think about the targeting system, so far it doesn't seem that effective. I don't know who else has played this game but did you guys kill the overseer? I did thinking I was doing a good deed but I kind of regret it, and I'm wondering what it's going to mean later in the game.