Do you use a spreadsheet? Nope. When drafting I like Funtons big board.
Do you use a set lineup? Probably 90% of the time. Obviously when players are having an off day you make the necessary switches, but I really try not to micromanage my lineup. I didn't bench Howard once the entire season (along with other '08 slow starters like Tex, Holliday, etc) because I know that my studs are going to produce eventually, so the stats will be there by the end of the year. I play H2H, so this doesn't work as well as it would in a roto league, but there's no need to second guess yourself on proven players.
How do you determine if you have enough to win your league? H2H is a crap shoot, so I just make sure I'll at least make the playoffs and at that point you just cross your fingers. But I still analyze my team and others and get a feel of where I stand throughout the season and make the necessary adjustments by working the FA's and WW along with making trades. Right now I've got 3 teams and all 3 are in 2nd place, so I should be set assuming the DL plague doesn't hit them all hard. The only I'll do is decided when I need to throw speed into my lineup, which is pretty self explanatory when you're in a H2H league.
Where do you get your projected stats? The main sources in yahoo/cbs, along with some cafe info, and some of my own.
I have determined that the WW and Free Agents is where the money is made in H2H leagues. A solid draft is obviously key, but every year I reap the benefits of Cafe info, personal "scouting", along with sleeper info on various websites. Last year it was Braun and Lincecum, this year it's been Volquez, McLouth, Bruce, Quentin, Sherrill, along with a few others, all of which that have made large impacts on my teams. Right now my teams are just about set, I'm going to deal maybe 2 or 3 players total in my 3 leagues and then just sit on my team and keep an eye on the WW. I'll make some moves if a problem presents itself, but right now all of my teams should be top 3 contenders form here on out.
Credit to smoovethug on the sig