Lose Conor Jackson at first base. There are better options out there (Kotchman, Billy Butler, Aubry Huff come to mind).
I'd lose Carlos Quentin, he's the odd man out in Chicagoland. I'd lose Julio Lugo and look to pick up a 2nd basemen. Use Escobar's versatility at 2nd and SS and get a better 2nd baseman. Perhaps someone like Geoff Blum who has multi-position eligibility or Aaron Hill if he's available. If you need speed perhaps Iwamura of the Rays may help you out.
Pitching wise I have NO IDEA who Jesus Colome is or why you even have him. Reyes is not worthy of holding onto, I'd look for replacements for these two pitchers. And I'd probably drop Mark Prior and look for a different DL option at Pitcher there (Mike Gonzalez, Kelvim Escobar come to mind)
help with mine? viewtopic.php?f=29&t=336953&sid=5a3a6157a6463a2c27328b8f717880bb#p2696452