Your two biggest needs appear to be Wins and batting avg (possibly Saves as well, depending on Marmol). Depending on the size of the league, you might want to consider punting batting avg and trying to win all other offensive categories (if the league is bigger, this is a better strategy). I would put Upton in the starting lineup in place of Kemp for right now, just because he is guaranteed a starting spot and Kemp is not. Also, I would start fielding offers for Tulowitski now. He's a solid shortstop, but you already have a star shortstop....make sure to get good value for him. It doesn't matter what position the person plays since he'll be taking up your Util spot, but I would suggest a 1b because a) yours are a little weak and b) people will give up better stats in a 1b than most positions.
As far as pitching goes you are set to win K's outright. You might consider trading Lincecum for someone who will deliver a better ERA, WHIP, and more wins, but with a lower K total. You don't need him for the K's since you have Kazmir and Bedard.