The current wins leaders, under 300 career wins, include Randy Johnson, Mike Mussina, David Wells, Jamie Moyer, Curt Schilling, and Pedro Martinez. I don't expect any of them to make 300, but there are a few younger guys that have a shot.
I think the two that have the best shots are Santana and Sabathia.
Zito, Zambrano, Buehrle, and Oswalt may get close. But it's not likely.
Does anyone think any of the current pitchers will win 300, or is Glavine the last of a dying breed for now?