Your OF and SP is your team's strength IMO. The only place where I can see an upgrade would be getting rid of Melvin Mora. I think he is past his prime and won't do much this season or beyond this season. Maybe package Mora with one of your OF, SP's or possibly 1B for an upgrade at CI. Thanks for your help with mine.
With Crawford, Sizemore and Ortiz, you're very strong at DH and in your outfield, but the rest of that lineup seems adequate at best.
Guys like Kent and Guillen, for example, will be productive when healthy but both routinely have injury concerns and will likely end up in the bottom half of the top 10 guys at their position. Basically, starter material, but not a strength. (And given Chipper's DL stint, he's obviously included there.)
You can live with those guys in your lineup, and Mora and Giles are probably pretty good second-tier infielders to have at MI and CI, but combined with your weakness at 1B that definitely does need to be addressed, I think you're going to be forced to deal either an elite pitcher or an elite hitter in return for a group of players that can fill a couple needs at once.
I'd be inclined to see if you can get someone to overbid on Smoltz, who's clearly a top pitcher if healthy but just skipped a start -- which could be nothing or could signal something serious.