What kind of scoring? If your league customarily carries only 2 RP's, I would definitely fish around to see what you could get. All 3 of yours are top shelf, so you should be able to get a stud in return. You could also use some help in the OF, Burrell may not be healthy, likewise for Drew. Good luck!
"This guy leads the league in most offensive categories, including nose hair..."
If most guys don't carry that many good closers, I'd hold there and just win saves.
If this is H2H with weekly matchups, absolutely drop Lo Duca to stream two start pitchers with favourable matchups.
If this isn't H2H with weekly matchups, still drop Lo Duca for the best SP/streaming spot.
If Johjima goes on the DL, then you pick up the 2nd catcher. No need to carry one now.
When Quentin goes on the DL (and that's looking very likely, of course), as I've typed in this forum 20 times this week, look at picking up a similar OF: high upside, youngster like Chris B. Young, Scott, Duncan, Hart, Gomes, and so on. That way, if he starts out really hot, you've got him before the word gets out, and Quentin can be dropped. That helps your thin OF a lot: two rookies for the price (roster slot) of one.
James was picked up? You play in a tougher league, I see.
Still you got the other "top" option.
Like I say, find a young OF you like for when Quentin goes on the DL. Otherwise, your team is pretty good.
You're going to need to keep an eye out for starters all year; that's why I would consider constantly streaming pitchers. I know it's frowned on, but you could do it over the course of 2 weeks at a time, just hitting good schedules and hot streaks by doing your research. You could win if you did that. Assuming Snell doesn't pitch like an all-star, which would make you win more easily.