I like the classic vacation with Griswold but Anchorman had some good lines like after the battle royal between the news teams:
Ron Burgundy: Boy, that escalated quickly... I mean, that really got out of hand fast.
Champ Kind: It jumped up a notch.
Ron Burgundy: It did, didn't it?
Brick Tamland: Yeah, I stabbed a man in the heart.
Ron Burgundy: I saw that. Brick killed a guy. Did you throw a trident?
Brick Tamland: Yeah, there were horses, and a man on fire, and I killed a guy with a trident.
Ron Burgundy: Brick, I've been meaning to talk to you about that. You should find yourself a safehouse or a relative close by. Lay low for a while, because you're probably wanted for murder.