As soon as Jimmy Fallon and Drew Barrymore hook up in a movie again, the Sox will be fine.
Technically, the Sox haven't won a World Series since that happened, so I think you could make a case for the Curse of Jimmy & Drew...
But seriously, it's obviously way too early to lose faith in the Sawx. Lord knows three games out is not insurmountable. They've got enough guys who can still produce, or at least the potential to do so, in the rotation, the lineup and even the bullpen. A bad stretch by the Yanks or ChiSox (with questions of their own), or a hot streak by the Sox, and things could be very different in a very short time. And yes, Wakefield coming back could be big. Keep the faith, as they say. (PS Go Yanks!
Of course, the World Series is probably out of reach for the Bosox AND the Yanks.