Basically what George said, grab one ace, then go and get mid level pitchers around the 10th round. YOU MUST GET PLENTY OF BATS. You can manipulate pitching matchups, double starts etc with your staff, but your hitters must be solid to produce week in and week out. I don't like to take a pitcher w/ my first two picks, you need to get absolute mashers with those picks. I would even lay off the guys like Utley. You wanna make sure you are getting guys that will absolutely hit around .300 w/ 35 HRs, 100+ RBIs and 100 Rs. Guys like Manny Ramirez, Bobby Abreu, etc. I try to get one guy that can win half the weeks of SBs for you (Pierre etc). You don't need dominant closers. Try to get a couple of mid level guys and a closer w/ potential (like George said, Devine).
C - wait, grab a guy like Lopez if you can, if not someone like R. Hernandez (Ha, i'm an O's fan)
1B - Very, Very deep, if 12 team league, you should definitely have a guy that gets you 30+ HRs w/ all the trimmings
2B - Don't reach for a 2B, wait until after the 10th round. Maybe grab a guy like F. Lopez that can help you w/ SBs. Cano and Polanco go late
SS - If you can get a Tejada in the 2nd, go ahead, otherwise, there is more depth then normal here. If you can get Jeter late 3rd or so, grab him there. You can grab guys like Crosby or Barmes real late though
3B - Very, very deep as well, you should have a guy that can pound it at third. DO NOT GET STUCK W/ GUYS LIKE Shea Hillenbrand here. That means someone else took 3B for their utility, trust me, I got stuck w/ a bad 3B last year and it sucks.
OF - The common belief here is that OF is deep, it's deep but there are a lot of positions to fill. Depending on how many utilities there are per team, usually about 50 OFs are in starting lineups. That means almost 2 from every team. FILL OUT YOUR OF EARLY!!! There are late round sleepers like Wilkerson and Hermida, but I still like to fill my OF in the first 6 rounds or so.
SP - One Ace, another guy like Webb hopefully and then a bunch of young guys or guys that should have big years (K. Escobar, C. Young etc)
RP - DO NOT TAKE CLOSERS IN THE FIRST 5 ROUNDS! True, they can help you in many categories, everything but wins, but they don't pitch enough innings. Your first 5 rounders should be studs in at least 4 categories
There you go, foulballstrike3's guide to drafting