I'm not sure I'd want to start a run with a corner pick. It depends on the calibre on the other managers in the league. If they're experienced, they probably won't bite on it and you'll be hung out to dry with 2 bats and 2 closers while others load up and get decent closers later on.
If you get 2 stud bats, you might consider taking 2 top pitchers if they are also safe picks, but there are few of those around.
Other than SP and closers, there aren't really any other runs that you could start.
[quote:4fef447375="Geek"]The odds of the AL MVP coming from the American League are looking pretty good.[/quote]