I'm pretty much non-partial myself this year, although I'm not a fan of being at the bookends in a snake. I feel that there's a moderate disadvantage the further you get from the middle picks for two reasons.
1) It's harder to jump in if a trend starts. If the two guys right after you grab two top-tier closers, for instance, chances are you'll miss out on them all.
2) You have less reaction time per pick. Yes, you have more total time between your picks, but a lot of drafting is dependant on what happens right before you pick, and you will have less time to react if you have to make two judgment calls in a row.
That second reason is a little iffy, and might be more mental than anything... but I guess I just feel rushed when I'm at the ends.